Contact Us

Ajijola Laboratory

650 Charles E Young Dr. S

CHS 37-300

Los Angeles, CA 90095

310-794-6695

ajijolalab@mednet.ucla.edu

Our Research

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Welcome to our lab.

 

We are a neurocardiology lab aimed at understanding the complex interplay between cardiac sympathetic innervation and cardiac electrical & contractile function. Our goal is to identify novel strategies to modulate the autonomic nervous system to treat & prevent cardiac arrhythmias, and sudden cardiac death.

 

Our lab is part of the UCLA Cardiac Arrhythmia Center & the UCLA Neurocardiology Program of Excellence.

News

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About the PI

Olujimi Ajijola MD PhD

Assistant Professor of Medicine

Our basic/translational research interests are focused on understanding how cardiac sympathetic innervation/function remodels in response to cardiac injury, and the mechanistic underpinnings of cardiac arrhythmogenesis in this setting. Using state-of-the-art electrical mapping techniques, we are able to study myocardial electrical propagation under a variety of sympathetic and parasympathetic loads. In addition to cardiac electrical mapping, other expertise includes intraganglionic neural recordings, targeted inductions of cardiovascular disease models.

From a clinical research perspective, we are interested in the application of neuro-modulatory therapies, as adjunctive therapies, for treating patients with minor and severe cardiac arrhythmias, and identifying biomarkers of autonomic function capable of identifying arrhythmia and sudden death risk.

The autonomic nervous system controls all aspects of cardiac function, including cardiac electrical properties. This occurs in both healthy states and following cardiac disease. In both situations, cardiac sympathetic activation can generate both the trigger for the initiation of dangerous heart rhythms, as well as the electrical substrates that enable those rhythms to persist. Shown below are some of the electrical effects of sympathetic activation on a normal heart, and a diseased heart following a heart attack (myocardial infarction).

AJP summary