650 Charles E Young Dr. S
Los Angeles, CA 90095
Welcome to our lab.
Associate Professor of Medicine
Our basic/translational research interests are focused on understanding how cardiac sympathetic innervation/function remodels in response to cardiac injury, and the mechanistic underpinnings of cardiac arrhythmogenesis in this setting. Using state-of-the-art electrical mapping techniques, we are able to study myocardial electrical propagation under a variety of sympathetic and parasympathetic loads. In addition to cardiac electrical mapping, other expertise includes intraganglionic neural recordings, targeted inductions of cardiovascular disease models.
The autonomic nervous system controls all aspects of cardiac function, including cardiac electrical properties. This occurs in both healthy states and following cardiac disease. In both situations, cardiac sympathetic activation can generate both the trigger for the initiation of dangerous heart rhythms, as well as the electrical substrates that enable those rhythms to persist. Shown below are some of the electrical effects of sympathetic activation on a normal heart, and a diseased heart following a heart attack (myocardial infarction).